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Increased plasma levels of big-endothelin-2 and big-endothelin-3 in patients with end-stage renal disease

✍ Scribed by Yumi Miyauchi; Satoshi Sakai; Seiji Maeda; Nobutake Shimojo; Shigeyuki Watanabe; Satoshi Honma; Keisuke Kuga; Kazutaka Aonuma; Takashi Miyauchi


Book ID
119318313
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
271 KB
Volume
91
Category
Article
ISSN
0024-3205

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## Abstract The complex pathogenesis of chronic renal disease (CRD) depends on endothelin (ET) axis (ETs and ET receptors) and nitric oxide (NO) because of their vasoactive effects and their role in general modulation of vascular homeostasis. Various renal cells synthesize ETs and NO that play a si