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Increased Phospholipase D Activity in Multidrug-Resistant Breast Cancer Cells

✍ Scribed by C.J. Welsh; G.C. Yeh; J.M. Phang


Book ID
115574945
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
399 KB
Volume
202
Category
Article
ISSN
0006-291X

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Multidrug resistance (MDR) is a major cause of failure of cancer chemotherapy and is often associated with elevated expression of drug transporters such as P-glycoprotein (P-gp) in the cancer cells. MDR is, however, accompanied by additional biochemical changes including modifications of membrane co