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Increased p38 mitogen-activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice cultures

✍ Scribed by Qing Lu; Thomas F. Rau; Valerie Harris; Maribeth Johnson; David J. Poulsen; Stephen M. Black


Book ID
109028646
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
539 KB
Volume
34
Category
Article
ISSN
0953-816X

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## Abstract 5‐Lipoxygenase (5‐LOX) is a key enzyme catalyzing arachidonic acid to form leukotrienes. We have reported that ischemic‐like injury activates 5‐LOX in PC12 cells; however, the mechanisms are unknown. To determine whether ischemic‐like injury activates 5‐LOX mediated by oxidative stress