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Increased O-demethylation rate of dextromethorphan in alcohol dependent patients. A possible role of ethanol in changing cytochrome P450 2D6 activity

✍ Scribed by B. Eisenburg; C.G. Schütz; J.P. Kuss; M. Heumüller; M. Soyka

Book ID
119574960
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
219 KB
Volume
10
Category
Article
ISSN
0924-977X

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Metabolism of Dextromethorphan in vitro:
Metabolism of Dextromethorphan in vitro: Involvement of Cytochromes P450 2D6 AND 3A3/4, with a Possible Role of 2E1
✍ JÜRGEN SCHMIDER; DAVID J. GREENBLATT; STEVEN M. FOGELMAN; LISA L. VON MOLTKE; RI 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB 👁 1 views

Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab