𝔖 Bobbio Scriptorium
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Increased number of hypothalamic [3H](+)-amphetamine binding sites in genetically obese (ob/ob) mice

✍ Scribed by R. Hauger; B. Hulihan-Glblin; S.M. Paul


Book ID
118955610
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
296 KB
Volume
25
Category
Article
ISSN
0028-3908

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The effect of metformin on hepatocyte insulin receptor binding was examined in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice. In normal mice, chronic administration of metformin (60 mg X kg-1 X day-1 for 50 weeks) increased the number of low affinity receptors by 148%.