Increased neurogenesis after experimental Streptococcus pneumoniae meningitis

✍ Scribed by Joachim Gerber; Tobias Böttcher; Judith Bering; Stephanie Bunkowski; Wolfgang Brück; Ulrich Kuhnt; Roland Nau

• Book ID: 102383388
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 232 KB
• Volume: 73
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.10682

✦ Synopsis

Abstract

Neuronal damage in the hippocampal formation is a common feature in animal models of bacterial meningitis and human disease. In mouse and rabbit models of Streptococcus pneumoniae meningitis, proliferation of neural progenitor cells quantified by bromodeoxyuridine (BrdU) incorporation was enhanced in the subgranular layer of the dentate gyrus. In mice, the density of BrdU‐labeled cells was maximal on Day 2 after infection. Approximately 60% of the cells labeled by BrdU between Days 7 and 10 after infection that remained present 28 days later had migrated into deeper layers of the dentate gyrus and differentiated into neurons, as evidenced by immunohistochemical staining for TUC‐4, MAP‐2 and beta‐tubulin. This suggests that endogenous repair mechanisms may limit consequences of neuronal destruction after meningitis. © 2003 Wiley‐Liss, Inc.