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Increased MMP expression and activity is associated with microvascular remodeling in a non-obese model of Type 2 diabetes

โœ Scribed by Kamakshi Sachidanandam; Alex Harris; WeiWei Song; Vera Portik-Dobos; Adviye Ergul


Book ID
113951675
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
51 KB
Volume
45
Category
Article
ISSN
1537-1891

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## Abstract Membraneโ€type metalloproteinaseโ€1 (MT1โ€MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of proโ€MMPโ€2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMPโ€2 activation that yields to t