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Increased midkine levels in sera from patients with Alzheimer's disease

✍ Scribed by Ragaa H.M. Salama; Hisako Muramatsu; Eiji Shimizu; Kenji Hashimoto; Shintaro Ohgake; Hiroyuki Watanabe; Naoya Komatsu; Naoe Okamura; Kaori Koike; Naoyuki Shinoda; Shin-ichi Okada; Masaomi Iyo; Takashi Muramatsu


Book ID
116840500
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
219 KB
Volume
29
Category
Article
ISSN
0278-5846

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Recently, the neurotoxic amyloid ␀-peptide was shown to up-regulate polyamine metabolism by increasing ornithine decarboxylase (ODC) activity and polyamine uptake by initiating free radical damage in Alzheimer's disease (AD). 1 Because of these findings, polyamines have been considered to play an im