Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

Overexpression of amyloid precursor prot

Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cells

✍ Amy J. Hanson; Judith E. Prasad; Piruz Nahreini; Cynthia Andreatta; Bipin Kumar; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 623 KB

Inflammatory reactions are considered one of the important etiologic factors in the pathogenesis of Alzheimer's disease (AD). Prostaglandins such as PGE 2 and PGA 1 and free radicals are some of the agents released during inflammatory reactions, and they are neurotoxic. The mechanisms of their actio