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Increased Levels of Mutagen-Induced Chromosome Breakage in Down Syndrome Children with Malignancy

✍ Scribed by Ravindran Ankathil; P Kusumakumary; M.Krishnan Nair


Book ID
114136307
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
87 KB
Volume
99
Category
Article
ISSN
0165-4608

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During a study of the familial aggregation of Down syndrome (DS) and Alzheimer disease (AD), we observed an increase in mosaicism for disomy 21 in older individuals with DS. In a total of 213 DS subjects who were studied cytogenetically, only 1 of 121 (0.8%) under age 45 exhibited mosaicism, while 1