Increased intracellular calcium is required for neurite outgrowth induced by a synthetic peptide ligand of NCAM

Modulation of neurotoxicant-induced incr

Modulation of neurotoxicant-induced increases in intracellular calcium by phytoestrogens differ for amyloid beta peptide (Aβ) and 1-methyl-4-phenyl-pyridine (MPP+)

✍ Izel Fourie Sørensen; Stig Purup; Marion Ehrich 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB

## Abstract Neurotoxicant‐induced elevation of intracellular calcium (Ca^2+^) and modulation by phystoestrogens were examined __in vitro__ using human neuroblastoma SH‐SY5Y cells cultured with amyloid beta‐peptide (A__β__) and 1‐methyl‐4‐phenyl‐pyridine (MPP+). Although A__β__ itself did not increa