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Increased inducible nitric oxide synthase protein but limited nitric oxide formation occurs in astrocytes of the hph-1 (tetrahydrobiopterin deficient) mouse

✍ Scribed by Jane E Barker; H.Maria Strangward; Michael P Brand; Roger D Hurst; John M Land; John B Clark; Simon J.R Heales

Book ID
114004114
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
110 KB
Volume
804
Category
Article
ISSN
0006-8993

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✍ Anna Chiarini; Ilaria Dal Pra; Rossella Gottardo; Federica Bortolotti; James F. 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 321 KB 👁 2 views

## Abstract Nitric oxide (NO) from astrocytes is one of the signalers used by the brain's extensive glial‐neuronal‐vascular network, but its excessive production by pro‐inflammatory cytokine‐stimulated glial cells can be cytodestructive. Here, we show how three pro‐inflammatory cytokines (IL‐1β, TN