Recent evidence suggests that macrophages and/or other nonparenchymal cells may release important mediators contributing to the hepatic necrosis induced by high doses of acetaminophen (APAP). The nature and causative role of these mediators has remained elusive, however. To investigate the role of t
Increased hepatotoxicity of acetaminophen in Hsp70i knockout mice
β Scribed by J. Keith Tolson; David J. Dix; Richard W. Voellmy; Stephen M. Roberts
- Book ID
- 113923813
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 290 KB
- Volume
- 210
- Category
- Article
- ISSN
- 0041-008X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In this research we examined the influence of chronic retrovirus infection on the hepatic metabolism of a model substrate, acetaminophen (APAP), and its induced liver injury in mice inoculated with LP-BMS murine leukemia viruses. Female C57BL/6 mice at 15-17 wks after LP-BMS retrovirus inoculation a
The hepatotoxicity of several drugs is increased by mild viral infections. During such infections, death receptor ligands are expressed at low levels, and most parenchymal cells survive. We tested the hypothesis that subliminal death receptor stimulation may aggravate the hepatotoxicity of drugs, wh