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Increased hepatic nicotine elimination after phenobarbital induction in the conscious rat

✍ Scribed by H. Foth; U.I. Walther; G.F. Kahl

Book ID
113207443
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
916 KB
Volume
105
Category
Article
ISSN
0041-008X

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✍ Foth, H. ;Aubrecht, J. ;H�hne, M. ;Walther, U.I. ;Kahl, G.F. 📂 Article 📅 1992 🏛 Springer-Verlag 🌐 English ⚖ 738 KB

The metabolic fate of cotinine, the major metabolite of nicotine, was studied in phenobarbital-induced and non-induced isolated perfused rat lung and liver and in isolated hepatocytes of rats and mice. The non-induced lung tissue showed low cotinine metabolizing capacity while the perfused liver was