Increased heinz body formation and impaired erythrocyte pentose phosphate shunt function during pregnancy

Impaired pentose phosphate shunt functio

Impaired pentose phosphate shunt function in sickle cell disease: A potential mechanism for increased heinz body formation and membrane lipid peroxidation

✍ Neil A. Lachant; Warren D. Davidson; Kouichi R. Tanaka 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 774 KB

The red cells' antioxidant defense mechanisms were compared between individuals with sickle cell disease and those with hemolytic anemia and reticulocytosis. In sickle cell disease, there was a significant increase in incubated Heinz body formation (p < .001), a decrease in reduced glutathione conce