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Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus

✍ Scribed by W. Tetzlaff; M. B. Graeber; M. A. Bisby; G. W. Kreutzberg


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
670 KB
Volume
1
Category
Article
ISSN
0894-1491

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✦ Synopsis


Glial fibrillary acidic protein (GFAP) increases in astrocytes following axotomy of facial motoneurons. In the present study we quantified GFAP synthesis both in regenerating facial nuclei after nerve crush and in nonregenerating facial nuclei after nerve resection. An increase in GFAP synthesis during regeneration occurs as early as 24 h after the axotomy. Thus, the increase in the astrocytic GFAP synthesis seems to be the earliest glial response to retrograde changes in facial motoneurons.


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