Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a c
Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus
β Scribed by W. Tetzlaff; M. B. Graeber; M. A. Bisby; G. W. Kreutzberg
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 670 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0894-1491
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β¦ Synopsis
Glial fibrillary acidic protein (GFAP) increases in astrocytes following axotomy of facial motoneurons. In the present study we quantified GFAP synthesis both in regenerating facial nuclei after nerve crush and in nonregenerating facial nuclei after nerve resection. An increase in GFAP synthesis during regeneration occurs as early as 24 h after the axotomy. Thus, the increase in the astrocytic GFAP synthesis seems to be the earliest glial response to retrograde changes in facial motoneurons.
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