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Increased gene copy number of KIT and VEGFR2 at 4q12 in primary breast cancer is related to an aggressive phenotype and impaired prognosis

✍ Scribed by Ida Johansson; Kristina E. Aaltonen; Anna Ebbesson; Dorthe Grabau; Caroline Wigerup; Ingrid Hedenfalk; Lisa Rydén

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
944 KB
Volume
51
Category
Article
ISSN
1045-2257

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Increased gene copy number of KIT and VE
Increased gene copy number of KIT and VEGFR2 at 4q12 in primary breast cancer is related to an aggressive phenotype and impaired prognosis
✍ Ida Johansson; Kristina E. Aaltonen; Anna Ebbesson; Dorthe Grabau; Caroline Wige 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 944 KB

## Abstract Triple‐negative breast cancer (TNBC) is associated with poor prognosis and no targeted treatments are available for TNBC. Drugs inhibiting tyrosine kinases, such as vascular endothelial growth factor receptor 2 (VEGFR2) and KIT, have shown some promising results for patients with TNBC.