Increased frequency of dicentric chromosomes in therapy-related MDS and AML compared to de novo disease is significantly related to previous treatment with alkylating agents and suggests a specific susceptibility to chromosome breakage at the centromere

Duplication or amplification of chromoso

Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents

✍ Mette K. Andersen; Debes H. Christiansen; Maria Kirchhoff; Jens Pedersen-Bjergaa 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 266 KB 👁 1 views

## Abstract Gene amplification is a rare phenomenon in acute leukemia, but recently amplification of specific chromosome bands containing genes rearranged in leukemia‐specific balanced chromosome translocations has been reported in a few cases. We detected duplication or amplification of chromosome