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Increased formation of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes

✍ Scribed by Akira Matsui; Tadashi Ikeda; Kohji Enomoto; Kanae Hosoda; Hiroshi Nakashima; Kazuyuki Omae; Mamoru Watanabe; Toshifumi Hibi; Masaki Kitajima


Book ID
117469777
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
163 KB
Volume
151
Category
Article
ISSN
0304-3835

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Oxidative DNA damage and 8-hydroxy-2-deo
✍ Donghui Li; Weiqing Zhang; Jijiang Zhu; Ping Chang; Aysegul Sahin; Eva Singletar 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 485 KB 👁 1 views

To test the hypothesis that oxidative stress is involved in breast cancer, we compared the levels of 8-hydroxy-2-deoxyguanosine (8-oxo-dG), an oxidized DNA base common in cells undergoing oxidative stress, in normal breast tissues from women with or without breast cancer. We found that breast cancer