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Increased Extracellular Brain Glutamate in Acute Liver Failure: Decreased Uptake or Increased Release?

✍ Scribed by Christopher Rose


Book ID
110412836
Publisher
Springer
Year
2002
Tongue
English
Weight
138 KB
Volume
17
Category
Article
ISSN
0885-7490

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L-ornithine phenylacetate attenuates inc
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Hyperammonemia is a feature of acute liver failure (ALF), which is associated with increased intracranial pressure (ICP) and brain herniation. We hypothesized that a combination of L-ornithine and phenylacetate (OP) would synergistically reduce toxic levels of ammonia by (1) L-ornithine increasing g