Increased expression of the tight junction molecule claudin-18 A1 in both experimental colitis and ulcerative colitis

✍ Scribed by Antonie Zwiers; Ivan J. Fuss; Suzanne Leijen; Chris J. Mulder; Georg Kraal; Gerd Bouma

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 180 KB
• Volume: 14
• Category: Article
• ISSN: 1078-0998
• DOI: 10.1002/ibd.20695

✦ Synopsis

Background:

We previously identified a major quantitative trait locus (qtl) on mouse chromosome 9 (Tnbs1) that confers resistance/ susceptibility to trinitrobenzene sulfonic acid (TNBS) induced colitis. Here we wanted to identify possible candidate genes in this locus.

Methods:

We applied micro-array technology and identified claudin-18 as a plausible candidate gene in the Tnbs1 region. Subsequently we studied the expression profile of this gene by means of RT-PCR in resistant and susceptible mice as well as in human inflammatory bowel disease.