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Increased expression of the integral membrane proteins EGFR and FGFR3 in anti-apoptotic Chinese hamster ovary cell lines

✍ Scribed by Erika Ohsfeldt; Szu-Han Huang; Deniz Baycin-Hizal; Linda Kristoffersen; Thuy-My T. Le; Edwin Li; Kalina Hristova; Michael J. Betenbaugh


Book ID
112008004
Publisher
Portland Press
Year
2012
Tongue
English
Weight
376 KB
Volume
59
Category
Article
ISSN
0885-4513

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## Abstract Mammalian cells are used for the production of numerous biologics including monoclonal antibodies. Unfortunately, mammalian cells can lose viability at later stages in the cell culture process. In this study, the effects of expressing the anti‐apoptosis genes, __E1B‐19K__ and __Aven__,