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Increased expression of the FoxP3 functional marker of regulatory T cells following B cell depletion with rituximab in patients with lupus nephritis

✍ Scribed by P.P. Sfikakis; V.L. Souliotis; K.G. Fragiadaki; H.M. Moutsopoulos; J.N. Boletis; A.N. Theofilopoulos


Book ID
113539503
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
440 KB
Volume
123
Category
Article
ISSN
1090-2341

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Functional type 1 regulatory T cells dev
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Mutations of forkhead box p3 (__FOXP3__), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The rel