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Increased expression of endothelial cell nitric oxide synthase (ecNOS) in afferent and glomerular endothelial cells is involved in glomerular hyperfiltration of diabetic nephropathy

✍ Scribed by H. Sugimoto; K. Shikata; M. Matsuda; M. Kushiro; Y. Hayashi; K. Hiragushi; J. Wada; H. Makino

Publisher: Springer
Year: 1998
Tongue: English
Weight: 231 KB
Volume: 41
Category: Article
ISSN: 0012-186X
DOI: 10.1007/s001250051088

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## Abstract Proliferative modification of vascular smooth muscle cell (vSMC) and impaired bioavailability of nitric oxide (NO) have both been proposed among the mechanisms linking diabetes and atherosclerosis. However, diabetes induced modifications in phenotype and nitric oxide synthase(s) (NOS) e