Increased expression of dopamine receptors on lymphocytes in Parkinson's disease

✍ Scribed by Piero Barbanti; Giovanni Fabbrini; Alberto Ricci; Rosanna Cerbo; Elena Bronzetti; Brunella Caronti; Caterina Calderaro; Laura Felici; Fabrizio Stocchi; Giuseppe Meco; Francesco Amenta; Gian Luigi Lenzi

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 118 KB
• Volume: 14
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/1531-8257(199909)14:5<764::aid-mds1008>3.0.co;2-w

✦ Synopsis

Dopamine D1-like and D2-like receptors on peripheral blood lymphocytes (PBL) were assayed in 50 de novo patients with idiopathic Parkinson's disease (PD), in 36 neurologic control subjects (multiple-system atrophy, n ‫ס‬ 16; essential tremor, n ‫ס‬ 10; other neurodegenerative diseases, n ‫ס‬ 10), and in 26 healthy control subjects by radioligand binding assay techniques using [ 3 H]SCH 23390 and [ 3 H]7OH-DPAT as ligands. Patients with PD revealed a higher density (Bmax) of dopamine D1-like (p <0.001) and D2-like (p <0.00001) receptors on PBL than either neurologic or healthy control subjects, whereas no differences in Bmax were observed among patients affected by other neurologic diseases and healthy control subjects. The affinity (Kd) of both radioligands was similar in the