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Increased expression of DNA-dependent protein kinase confers resistance to adriamycin

✍ Scribed by Hongxie Shen; Mary Schultz; Gary D Kruh; Kenneth D Tew

Book ID
117481664
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
231 KB
Volume
1381
Category
Article
ISSN
0304-4165

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## Abstract DNA‐dependent protein kinase (DNA‐PK), a nuclear serine/threonine kinase, is responsible for the DNA double‐strand break repair. Cells lacking or with dysfunctional DNA‐PK are often associated with mis‐repair, chromosome aberrations, and complex exchanges, all of which are known to cont