We have demonstrated over-expression of the cyclindependent kinase inhibitor p21 in various ovarian-cancer cell lines as well as in ovarian-tumor biopsies. This increase in p21 expression relative to that observed in normal ovarian epithelial cells is unrelated to proliferation index. In the present
Increased expression of cyclin E is associated with an increased resistance to doxorubicin in rat fibroblasts
β Scribed by Sgambato, A; Camerini, A; Pani, G; Cangiano, R; Faraglia, B; Bianchino, G; De Bari, B; Galeotti, T; Cittadini, A
- Book ID
- 109997586
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 209 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract To search for a marker that predicts the efficacy of radiation therapy in human cervical cancer, gene expression profiles between parental SiHa cervical cancer cells and radiationβresistant SiHa/R cells have been compared by the microarray technique. Microarray and Northern blot analyse
## Abstract Overexpression of the Pβglycoprotein/multidrug resistance 1 __(MDR1)__ and multidrug resistance protein 1 __(MRP1)__ gene is closely associated with the clinical outcome of various malignancies, and it is involved in responses to some anticancer chemotherapeutic agents including doxorub
The failure of chemotherapy is often associated with the failure of radiotherapy in the treatment of cancer. To investigate this relationship, the CCRF-CEM (CEM) human T-cell leukaemia cell line was treated with fractionated β₯-radiation totalling 75 Gy (10 cycles of 1.5 Gy daily for 5 days). This pr
## Abstract Cyclin D1 is a wellβknown cell cycle regulator. Recently, its proβsurvival function has been revealed in several tumors. Because increasing expression of cyclin D1 is a common event in oral squamous cell carcinoma (OSCC) and has been correlated with cisplatin resistance, we investigated