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Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts

✍ Scribed by Kristin Schram; Maggie M.C. Wong; Rengasamy Palanivel; Eun Kyung No; Ian M.C. Dixon; Gary Sweeney


Book ID
116985678
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
658 KB
Volume
44
Category
Article
ISSN
0022-2828

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## Abstract Membrane‐type metalloproteinase‐1 (MT1‐MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro‐MMP‐2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP‐2 activation that yields to t