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Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer

✍ Scribed by Liu, Chunyan; Zhou, Shaoyu; Begum, Shahnaz; Sidransky, David; Westra, William H.; Brock, Malcolm; Califano, Joseph A.


Book ID
119319532
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
886 KB
Volume
55
Category
Article
ISSN
0169-5002

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## Abstract We observed a 53% response rate in non‐small cell lung cancer (NSCLC) patients treated with vorinostat plus paclitaxel/carboplatin in a Phase I trial. Studies were undertaken to investigate the mechanism (s) underlying this activity. Growth inhibition was assessed in NSCLC cells by MTT