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Increased Exploratory Activity and Altered Response to LSD in Mice Lacking the 5-HT5A Receptor

✍ Scribed by Régis Grailhe; Christian Waeber; Stephanie C Dulawa; Jean P Hornung; Xiaoxi Zhuang; Dani Brunner; Mark A Geyer; René Hen

Book ID
117607217
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
243 KB
Volume
22
Category
Article
ISSN
0896-6273

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✍ Stork, Oliver ;Welzl, Hans ;Wotjak, Carsten T. ;Hoyer, Daniel ;Delling, Markus ; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB 👁 1 views

Mice deficient in the neural cell adhesion molecule (NCAM) show behavioral abnormalities as adults, including altered exploratory behavior, deficits in spatial learning, and increased intermale aggression. Here, we report increased anxiety-like behavior of homozygous (NCAM ؊/؊ ) and heterozygous (NC