๐”– Bobbio Scriptorium
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INCREASED ENZYME ACTIVITY IN VITRO AND METABOLISM OF SUBSTRATES IN VIVO


Book ID
114907744
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
237 KB
Volume
27
Category
Article
ISSN
0029-6643

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Species differences in in vitro and in v
โœ Hiroshi Komura; Masahiro Iwaki ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 272 KB ๐Ÿ‘ 1 views

Intestinal first-pass metabolism has a great impact on the bioavailability of CYP3A substrates in humans, and the in vivo impact has quantitatively been evaluated using CYP3A inhibitors or inducers. In vitro and in vivo preclinical investigations for intestinal metabolism are essential in clarifying