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Increased efficiency of homologous recombination in ES cells by cleavage at both ends of homology in the targeting vector

✍ Scribed by Rachel Sarig; Valerie Mezger-Lallemand; Sigalit Leibovitz; Uri Nudel

Book ID
110272035
Publisher
Springer Netherlands
Year
2000
Tongue
English
Weight
20 KB
Volume
9
Category
Article
ISSN
0962-8819

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Disruption of the genomic imprint in trans with homologous recombination at Snrpn in ES cells
✍ Ting-Fen Tsai; Jan Bressler; Yong-hui Jiang; Arthur L. Beaudet πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 394 KB

## Abstract Summary: In gene targeting studies of the Prader‐Willi syndrome (PWS)/Angelman syndrome (AS) domain in mouse ES cells, we recovered only recombinants with the paternal allele for constructs at exons 2 or 3 of the imprinted, maternally silenced __Snurf‐Snrpn__ gene. These sites lie close