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Increased cytoprotective function in the liver of transgenic mice expressing osteopontin in hepatocytes

✍ Scribed by Hea Saeng Koh; Atsushi Matsui; Sumie Mimura; Mie Inao; Eiko Saitoh; Akihiko Ohno; Sumiko Nagoshi; Takayuki Yoshimoto; Satoshi Mochida; Kenji Fujiwara

Book ID
108138224
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
387 KB
Volume
32
Category
Article
ISSN
1386-6346

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## Cyclooxygenase -2 (COX-2) is upregulated in many cancers, and the prostanoids synthesized increase proliferation, improve angiogenesis, and inhibit apoptosis in several tissues. To explore the function of COX-2 in liver, transgenic (Tg) mice were generated containing a fusion gene (LIVhCOX-2) c