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Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9

✍ Scribed by Elzbieta Kolaczkowska; Barbara Plytycz; Bernd Arnold; Helene Piccard; Ghislain Opdenakker

Book ID: 108782439
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 406 KB
Volume: 128
Category: Article
ISSN: 0019-2805
DOI: 10.1111/j.1365-2567.2008.02956.x

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✍ P. E. Gottschall; X. Yu; B. Bing 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 778 KB

Activated macrophages produce several matrix metalloproteinases (MMPs), a family of extracellular matrix (ECM)-degrading enzymes, during wound healing and in other inflammatory states. In response to brain injury, brain microglia become "activated," in a way similar to peripheral tissue macrophages,