Increased cell proliferation activity and decreased cell death are associated with the emergence of hormone-refractory recurrent prostate cancer
✍ Scribed by Koivisto, Pasi; Visakorpi, Tapio; Rantala, Immo; Isola, Jorma
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 242 KB
- Volume
- 183
- Category
- Article
- ISSN
- 0022-3417
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✦ Synopsis
The tumour growth kinetics (cell proliferation and apoptosis) of ten hormone-refractory locally recurrent prostate cancers were compared with their matched untreated primary tumour specimens. All recurrent tumours had a higher cell proliferation activity, as defined by Ki-67 immunohistochemistry, than corresponding primary tumours from the same patients. The mean cell proliferation activity in recurrences (13•5 3•8 per cent) was over two times higher (P<0•0001) than that in primary tumours (5•5 2•4 per cent), suggesting that cell clones which progress during androgen withdrawal are actively stimulated to proliferate. The mean percentage of apoptotic cells, as estimated by the in situ end-labelling technique, was 5•4 4•7 per cent in untreated primary tumours, whereas it was 2•3 1•5 per cent in locally recurrent tumours (P=0•05). In all but two cases, the apoptotic index was lower in recurrent than in corresponding primary tumours, suggesting that recurrent prostate carcinomas are able to avoid apoptosis in the androgen-deprived environment. In conclusion, the clinical progression of prostate cancer during androgen withdrawal is associated with increased cell proliferation and decreased apoptosis. 1997 by John Wiley & Sons, Ltd.