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Increased calpain content and progressive degradation of neurofilament protein in spinal cord injury

โœ Scribed by Naren L. Banik; Denise C. Matzelle; Gloria Gantt-Wilford; Anne Osborne; Edward L. Hogan


Book ID
114002309
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
752 KB
Volume
752
Category
Article
ISSN
0006-8993

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New inhibitors of calpain prevent degrad
โœ T. James; D. Matzelle; R. Bartus; E.L. Hogan; N.L. Banik ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 66 KB ๐Ÿ‘ 1 views

We have determined the effects of the calpain inhibitors AK275 and AK295 upon purified m-calpain and calcium-mediated degradation of neurofilament protein (NFP) in rat spinal cord in vitro. After incubation, the soluble radioactivity and/or extent of myelin basic protein (MBP) or NFP degradation was