Increased bone resorption with decreased activity and increased recruitment of osteoblasts in osteogenesis imperfecta type I
β Scribed by Jun Iwamoto; Tsuyoshi Takeda; Shoichi Ichimura
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 87 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0914-8779
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## Abstract The current study addresses whether alterations in osteoclasts (OCs) derived from __oim/oim__ mice, an established model of moderateβtoβsevere OI, are present. Bone marrow cells from __oim/oim__ and wildtype (+/+) mice were cultured on bone slices in the presence of MCSF and RANKL and e
In three cases of type IV osteogenesis imperfecta (OI), we identified unique point mutations in type I collagen alpha1(I) cDNA. In two cases, the appearance of dimers indicated the presence of cysteine substitutions in the alpha1(I) protein chain. Cyanogen bromide digestion localized these cross-lin