Increased blood levels of methyl tert-butyl ether but not of ethyl propionate during instillation with contact gallstone dissolution agents in the pig
✍ Scribed by Oliver Esch; Claudio D. Schteingart; Dirk Pappert; Diane Kirby; Rita Streich; Alan F. Hofman
- Book ID
- 102852290
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 831 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
We performed experiments in anesthetized piglets with two cholesterol gallstone solvents, methyl tertbutyl ether and ethyl propionate, to determine whether blood levels of either solvent would increase during gallbladder instillation of these solvents under conditions simulating gallstone dissolution. The solvent was oscillated rapidly in and out of the gallbladder with a computer-controlled syringe pump; intraluminal pressure was set below the leakage pressure, and oscillating volume was set below the leakage volume to decrease loss of solvent into the intestine. Blood levels were measured with gas chromatography. Six piglets received methyl tert-butyl ether, and six piglets received ethyl propionate. During 2 hr of instillation with methyl tert-butyl ether, blood levels increased steadily to concentrations averaging 0.3 mlL blood at 2 hr; during a 6-hr period of instillation, blood levels rose to above 0.4 m l L blood. Replacement of methyl tert-butyl ether with saline solution in the gallbladder caused blood levels to decline gradually; plasma levels decreased by half in 90 min. In contrast, when ethyl propionate was infused for 2 or 6 hr, blood levels remained below the detection limit, probably because of high first-pass hepatic ex-