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Increased biological potency of hexafluorinated analogs of 1,25-dihydroxyvitamin D3 on bovine parathyroid cells

✍ Scribed by Yasuo Imanishi; Masaaki Inaba; Hitoshi Seki; Hidenori Koyama; Yoshiki Nishizawa; Hirotoshi Morii; Shuzo Otani

Book ID
117669229
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
148 KB
Volume
70
Category
Article
ISSN
0960-0760

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Hexafluoro-1,25-dihydroxyvitamin D3 has
Hexafluoro-1,25-dihydroxyvitamin D3 has markedly increased potency in inhibiting proliferation of cultured human keratinocytes compared with 1,25-dihydroxyvitamin D3
✍ T.C. Chen; M.F. Holick πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 409 KB

## Background: Although topical 1,25-dihydroxyvitamin d3 (calcitriol, 1, 25(oh)2d3) and its analogues, calcipotriol and tacalcitol, are effective for patients with psoriasis, some patients show little or no response. there is a need to develop more potent analogues of 1, 25(oh)2d3. hexafluoro-1,25(