Increased bile acid pool inhibits cholesterol 7 alpha-hydroxylase in cholesterol-fed rabbits
โ Scribed by G Xu; G Salen; S Shefer; GS Tint; BT Kren; LB Nguyen; CJ Steer; TS Chen; L Salen; D Greenblatt
- Book ID
- 118519723
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 309 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0016-5085
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plasma cholesterol levels in NZW rabbits. Hypercholes-The effect of bile acid depletion and replacement with terolemia in WHHL rabbits was related to the combinaglycodeoxycholic acid on plasma cholesterol concentration of dysfunctional LDL receptors and inhibited tions, hepatic low-density lipoprote
Bile acid synthesis in the liver is regulated by the rate-limiting enzyme cholesterol 7โฃ-hydroxylase (CYP7A1). Transcription of the CYP7A1 gene is inhibited by bile acids and cytokines. The rate of bile acid synthesis is reduced immediately after partial hepatectomy and during the early stage of liv