Increased asymmetric dimethylarginine and endothelin 1 levels in secondary Raynaud's phenomenon: Implications for vascular dysfunction and progression of disease
✍ Scribed by Sanjay Rajagopalan; Dana Pfenninger; Christine Kehrer; Anjan Chakrabarti; Emily Somers; Robert Pavlic; Debabrata Mukherjee; Robert Brook; Louis G. D'Alecy; Mariana J. Kaplan
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 101 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Objective
To compare microvascular and macrovascular functions in a cohort of patients with primary and secondary Raynaud's phenomenon (RP) who were matched for demographic, risk factor, and severity profiles.
Methods
Forty patients with primary or secondary RP matched for vascular risk factors and severity scores underwent testing of endothelial function and cold pressor responsiveness of the brachial artery. Microvascular perfusion of the digital vasculature was assessed using laser Doppler fluxmetry in response to reactive hyperemia. Plasma was assayed for endothelin 1 (ET‐1), asymmetric dimethylarginine (ADMA), intercellular adhesion molecule 1, vascular cell adhesion molecule 1 (VCAM‐1), and monocyte chemoattractant protein 1 (MCP‐1).
Results
Patients with RP had abnormal vasoconstrictor responses to cold pressor tests (CPT) that were similar in primary and secondary RP. There were no differences in median flow‐mediated and nitroglycerin‐mediated dilation or CPT of the brachial artery in the 2 populations. Patients with secondary RP were characterized by abnormalities in microvascular responses to reactive hyperemia, with a reduction in area under the curve adjusted for baseline perfusion, but not in time to peak response or peak perfusion ratio. Plasma ET‐1, ADMA, VCAM‐1, and MCP‐1 levels were significantly elevated in secondary RP compared with primary RP. There was a significant negative correlation between ET‐1 and ADMA values and measures of microvascular perfusion but not macrovascular endothelial function.
Conclusion
Secondary RP is characterized by elevations in plasma ET‐1 and ADMA levels that may contribute to alterations in cutaneous microvascular function.