## Abstract We have analyzed the gene modulation induced by zoledronic acid (ZOL) in androgen‐resistant prostate cancer PC3 cells with cDNA microarray platform to identify new molecular targets of ZOL in prostate cancer. The gene coding for cysteine‐rich, angiogenic inducer, 61 (CYR61) resulted hig
✦ LIBER ✦
Increased anti-tumour effects of doxorubicin and zoledronic acid in prostate cancer cells in vitro: supporting the benefits of combination therapy
✍ Scribed by Rhys D. Clyburn; Penny Reid; Catherine A. Evans; Diane V. Lefley; Ingunn Holen
- Book ID
- 105993251
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 375 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## Background We proposed to exploit hypoxia‐inducible factor (HIF)‐1α overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF‐1α to arrangements of hypoxia response elements.