Increased alkaline phophatase activity in HeLa cells mediated by aliphatic monocarboxylates and inhibitors of DNA synthesis
β Scribed by Deutsch, Stephen I.; Ghosh, Nimai K.; Cox, Rody P.
- Book ID
- 125473846
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 582 KB
- Volume
- 499
- Category
- Article
- ISSN
- 0304-4165
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HeLa cells in monolayer cultures were treated with the following inhibitors of DNA synthesis: mitomycin C, nitrogen mustard, fluorodeoxyuridine, hydroxyurea, arabinofuranosylcytosine and high concentrations of thymidine. The concentration of each inhibitor used was, in most cases, just sufficient to
## Abstract The three xanthine derivatives, caffeine, theophylline and 3βisobutylβ1βmethylβxanthine (IBMX) produced doseβdependent increases in cyclic AMP concentrations in HeLa cells after long term treatment. Only IBMX produced increases over the first 60 minutes, with a peak of approximately 5βf