Increased 5HT-induced platelet aggregation in mania: Lack of change following neuroleptic medication
✍ Scribed by Joseph Meagher; B. E. Leonard
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 449 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
Nineteen patients with mania were compared to a group of 15 schizophrenic patients and age, sex matched controls with respect to changes in SHT-induced platelet aggregation. In the manic patients aggregation rates were monitored immediately before the commencement of standard neuroleptic treatment (chlorpromazine, haloperidol), on days 4, 8, 15 and following discharge from hospital. The 5HT-induced aggregation rate was increased in the manic patients compared with their controls and the schizophrenics and did not return to control levels at the end of the study period when the patients were apparently well. There was no correlation between the increased SHT-induced aggregation and the Young Manic Score. No change occurred in the aggregation rate to noradrenaline and adrenaline in either the manic or schizophrenia patients.
The results suggest that increased SHT-induced platelet aggregation may be a trait marker of mania.
KEY woms-Mania, schizophrenia, SHT-induced platelet aggregation, trait marker of mania.