𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Increase of lymphocyte-mediated tumor-cell destruction by certain patient sera

✍ Scribed by Ingegerd Hellström; Karl Erik Hellström; Glenn A. Warner

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
437 KB
Volume
12
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Sera from one patient with an ovarian carcinoma, one with sarcoma, one with a breast carcinoma, and four patients with melanoma were found to “potentiate” (i.e. increase) the cytotoxic effect of blood lymphocytes reactive to the respective type of tumor target cells. This effect was specific. Furthermore, sera from the breast cancer and sarcoma patients and from one of the melanoma patients “armed” (i.e. made cytotoxic) lymphocytes from non‐reactive donors, not having (had) the respective tumor studied. The possible relevance, in vivo, of these findings, and the frequency with which they occur, need further clarification.

📜 SIMILAR VOLUMES

Blocking of cell-mediated tumor immunity
Blocking of cell-mediated tumor immunity by sera from patients with growing neoplasms
✍ Ingegerd Hellström; Hans Olov Sjögren; Glenn Warner; Karl Erik Hellström 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 779 KB

## Abstract Blood lymphocytes from tumor patients can specifically destroy cultivated neoplastic cells of the same histological origin as the tumors of the lymphocyte donors, irrespective of whether or not the donors have symptoms of growing tumor. The purpose of the present study was to investiga

Increased lymphocyte-mediated destructio
Increased lymphocyte-mediated destruction of tumor cells in microcytotoxicity assays seen after addition of inhibitors of protein synthesis
✍ I. Hellström; K. E. Hellström; J. T. Nepom 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 574 KB

## Abstract Two methylcholanthrene (MCA)‐induced sarcomas were used as targets in a criss‐cross pattern to study lymph‐node‐cell (LNC)‐mediated cytotoxic reactions to tumor‐specific antigens in a 26 h microcytotoxicity assay. Destruction of plated tumor cells by syngeneic LNC from specifically tumo

Elution of “blocking factors” from human
Elution of “blocking factors” from human tumors, capable of abrogating tumor-cell destruction by specifically immune lymphocytes
✍ Hans Olov Sjögren; Ingegerd Hellström; Subhash C. Bansal; Glenn A. Warner; Karl 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 French ⚖ 622 KB

## Abstract Sera from patients with growing neoplasms have been previously shown capable of specifically blocking the cytotoxic effect of lymphocytes immune to tumor‐associated antigens (TAA) of the respective patients' neoplasms. The present investigation demonstrates that a similar blocking activ

Lymphocyte-mediated lysis of tumor cells
Lymphocyte-mediated lysis of tumor cells in vitro (ADCC), induced by serum antibodies from patients with urinary bladder carcinoma or from controls
✍ M. Troye; Y. Hansson; S. Paulie; P. Perlmann; H. Blomgren; B. Johansson 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 694 KB

## Abstract IgG fractions from serum of patients with transitional‐cell carcinoma of the urinary bladder (TCC), patients with carcinoma of the prostate (CC) and healthy donors (HD) were tested for their capacity to induce antibody‐dependent lymphocyte‐mediated cytotoxicity (ADCC) to tumor cells in