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Increase of creatine kinase activity in the visual cortex of human brain during visual stimulation: A 31p NMR magnetization transfer study

✍ Scribed by Wei Chen; Xiao-Hong Zhu; Gregor Adriany; Kǎmil Uǧurbil

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
677 KB
Volume
38
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

^31^P magnetic resonance spectroscopy was used to investigate changes in high energy phosphate levels and creatine kinase (CK) kinetics induced in the human visual cortex during photic stimulation. CK kinetics was evaluated by measuring the apparent unidirectional rate constant (k~f~) in the “forward” direction (i.e., in the direction of ATP synthesis from phosphocreatine). k~f~ increased 34% in the visual cortex areas during stimulation without significant changes of steady‐state concentration of high energy phosphate compounds, indicating that CK turnover is elevated during increased neuronal activity.

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