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Increase of collagen synthesis by obovatol through stimulation of the TGF-β signaling and inhibition of matrix metalloproteinase in UVB-irradiated human fibroblast

✍ Scribed by Choi, Myoung Suk; Yoo, Myung Sik; Son, Dong Ju; Jung, Hai Young; Lee, Seung Ho; Jung, Jae Kyung; Lee, Beom Cheon; Yun, Yeo Pyo; Pyo, Hyeong Bae; Hong, Jin Tae


Book ID
119293254
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
874 KB
Volume
46
Category
Article
ISSN
0923-1811

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## Abstract Human proximal tubule (HK‐2) cells are commonly used as cellular models to understand the mechanism by which inflammatory mediators cause renal injury. It has been observed that thrombin stimulates the expression of TGF‐β, extracellular matrix (ECM) proteins and proinflammatory cytokine