Increase of Bone Mass and Mechanical Strength in Rats after Treatment with a Novel Bisphosphonate, YM175, for Two Years

Maintaining bone mass by bisphosphonate

Maintaining bone mass by bisphosphonate incadronate disodium (YM175) sequential treatment after discontinuation of intermittent human parathyroid hormone (1-34) administration in ovariectomized rats

✍ Yuichi Takano; Tatsuhiko Tanizawa; Tasuku Mashiba; Naoto Endo; Saburo Nishida; H 📂 Article 📅 2009 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 791 KB

Intermittent treatment with human parathyroid hormone (1-34) ] stimulates bone formation and increases cancellous bone mass in ovariectomized (OW) rats. But PTH-induced cancellous bone rapidly disappears upon cessation of treatment. The fate of cortical bone treated by PTH has not been well characte