This study investigates the tolerability, safety and efficacy of abrupt or stepwise switching from donepezil to memantine treatment in patients with moderate-to-severe Alzheimer's disease (AD). Outpatients (Table 1), !50 years, with dementia of the Alzheimer's type (DSM-IV-TR), MMSE 18 and receiving
Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer’s disease
✍ Scribed by T. Leyhe; Elke Stransky; G. W. Eschweiler; G. Buchkremer; C. Laske
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 200 KB
- Volume
- 258
- Category
- Article
- ISSN
- 1433-8491
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## Abstract To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8‐hydroxyguanosine (8‐OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and control subjects. T
## Abstract ## Background The objective was to evaluate the efficacy and tolerability of donepezil (5 and 10 mg/day) compared with placebo in alleviating manifestations of mild to moderate Alzheimer's disease (AD). ## Method A systematic review of individual patient data from Phase II and III do