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Increase in GSK3β gene copy number variation in bipolar disorder

✍ Scribed by Herbert M. Lachman; Erika Pedrosa; Oriana A. Petruolo; Melissa Cockerham; Alexander Papolos; Tomas Novak; Demitri F. Papolos; Pavla Stopkova

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
101 KB
Volume
144B
Category
Article
ISSN
1552-4841

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Beta-defensins are a family of multifunctional genes with roles in defense against pathogens, reproduction, and pigmentation. In humans, six beta-defensin genes are clustered in a repeated region which is copy-number variable (CNV) as a block, with a diploid copy number between 1 and 12. The role in